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Zinc transporter 1

SLC30A1
Identifiers
AliasesSLC30A1, ZNT1, ZRC1, solute carrier family 30 member 1
External IDsOMIM: 609521 MGI: 1345281 HomoloGene: 6681 GeneCards: SLC30A1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SLC30A1
Genomic location for SLC30A1
Band1q32.3Start211,571,568 bp[1]
End211,579,161 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021194

NM_009579

RefSeq (protein)

NP_067017

NP_033605

Location (UCSC)Chr 1: 211.57 – 211.58 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.[4][5]

Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170385 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. doi:10.1002/j.1460-2075.1995.tb07042.x. PMC 398127. PMID 7882967.
  5. ^ Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973.
  6. ^ Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.

Further reading