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Zinc-activated ion channel

AliasesZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel
External IDsOMIM: 610935 HomoloGene: 52296 GeneCards: ZACN
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ZACN
Genomic location for ZACN
Band17q25.1Start76,071,961 bp[1]
End76,083,666 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 17: 76.07 – 76.08 Mbn/a
PubMed search[2]n/a
View/Edit Human

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.[3]

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.[3][4] The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.[3]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186919 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b c Davies PA, Wang W, Hales TG, Kirkness EF (January 2003). "A novel class of ligand-gated ion channel is activated by Zn2+". The Journal of Biological Chemistry. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
  4. ^ Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (September 2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochemical and Biophysical Research Communications. 335 (2): 277–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.