Wyckoff Heights is home to the Wyckoff Heights Medical Center at Wyckoff Avenue and Stockholm Street (originally the German Hospital of Brooklyn, renamed in 1918), and the former Wyckoff Heights Presbyterian Church at Harman Street and St. Nicholas Avenue (founded in 1895 and rebuilt after a 1928 fire, now the Ridgewood Pentecostal Church).
The Wyckoff Heights Post Office (zip code 11237) at 86 Wyckoff Avenue was opened in 1951 and serves north Bushwick and the Brooklyn portion of Wyckoff Heights.
The area was home first to many German immigrants, later followed by Italian and more recently Latino and Eastern-European residents.
Wyckoff Heights was urbanized starting in the late 1800s, and took its name from the Wyckoff family who owned and farmed much of the land. Development progressed from Brooklyn into Queens as portions of the Wyckoff farm were sold.
In 1892 Queens County property owners established the Wyckoff Heights Improvement Association to lobby for water, sewer, and gas service to the neighborhood, and in 1893 the Wyckoff Heights Water Company was formed to supply drinking water to the area.
In 1901 residents of the Queens section lobbied the City government to "adopt a system of house numbering" and erect street signs so that the postal service would begin delivery to the neighborhood. Mail delivery to the Queens section was provided by the Brooklyn Post Office from the early 1900s until 1979, when the Ridgewood/Glendale areas of Queens were granted their own zip code, 11385.
The last 18 acres (73,000 m2) of farmland were developed in the 1940s.
The first buildings constructed in the neighborhood were largely attached wood frame three- and six-family row houses.
Around the turn of the century, as urbanization moved northeast towards the borough line and into Queens, developers switched to masonry construction in order to conform to new building and fire codes. Many of these buildings are now part of the Cypress Avenue West Historic District.
In the 1940s the last large-scale development in the neighborhood saw the construction of more automobile-oriented attached single-family homes with alleys and garages in the rear.