|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||351.276 g/mol g·mol−1|
|3D model (JSmol)|
VU-0238429 is a drug which acts as a selective positive allosteric modulator for the muscarinic acetylcholine receptor M5. It was the first selective ligand developed for the M5 subtype, and is structurally derived from older M1-selective positive allosteric modulators such as VU-0119498. Replacing the O-methyl- by a phenylgroup further improves the receptor subtype selectivity (VU-0400265).