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Trifluoromescaline structure.png
Clinical data
ATC code
  • none
Chemical and physical data
Molar mass265.228 g/mol g·mol−1
3D model (JSmol)

Trifluoromescaline (TF-M) is a derivative of the phenethylamine hallucinogen mescaline, which has a trifluoromethoxy group replacing the central methoxy group of mescaline. Synthesis of this compound was first reported by Daniel Trachsel in 2011, alongside many other related compounds.[1][2] Trifluoromescaline was found to be one of the most potent compounds in the series, with a reported dosage of 15-40mg (and 60mg being described as a "strong overdose"), and a slow onset of action and long duration of effects, lasting 14-24 hours or more.[3]

See also


  1. ^ Trachsel D. Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur-Aktivitätsbeziehungen, Mitteilung 1, Mescalin Derivate. Helvetica Chimica Acta. 2002; 85(9):3019–3026. doi:10.1002/1522-2675(200209)85:9<3019::AID-HLCA3019>3.0.CO;2-4
  2. ^ Trachsel D. Fluorine in psychedelic phenethylamines. Drug Testing and Analysis. Dec 2011. doi: 10.1002/dta.413
  3. ^ Daniel Trachsel, David Lehmann and Christoph Enzensperger. Phenethylamine Von der Struktur zur Funktion, pp 704-723. Nachtschatten Verlag AG, 2013. ISBN 978-3-03788-700-4