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Chemical structure of alprazolam
, a common triazolobenzodiazepine
Triazolobenzodiazepines are a class of benzodiazepine pharmaceutical drugs. Chemically, they differ from other benzodiazepines by having an additional fused triazole ring.
Synthesis of 1-methyltriazolobenzodiazepines (alprazolam type) is possible by heating 1,4-benzodiazepin-2-thiones with hydrazine and acetic acid in n-butanol under reflux.
- ^ Hester JB, Duchamp DJ, Chidester CG (1971): "A synthetic approach to new 1,4-benzodiazepine derivatives." Tetrahedron Letters, Vol. 12, pp. 1609-1612.