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Thioproperazine

Thioproperazine
Thioproperazine.svg
Names
IUPAC name
N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.005.695
KEGG
UNII
Properties
C22H30N4O2S2
Molar mass 446.6292 g/mol
Pharmacology
N05AB08 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Thioproperazine, sold under the brand name Majeptil, is a typical antipsychotic of the phenothiazine group which is used as a tranquilizer, antiemetic, sedative, and in the treatment of schizophrenia and manic phase of bipolar disorder.[1][2][3][4] Majeptil is available in 10 mg tablets.[5]

Side Effects

Common[6]

  • Abnormal movements (extrapyramidal symptoms)
  • Changes in monthly menstrual cycle (amenorrhea)
  • Decreased sexual interest and/or function
  • Swelling of breasts and milk production in males and females
  • Difficulty sleeping
  • Constipation
  • Reduced amount of urine
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Nausea
  • Headache
  • Weight changes

Rare but potentially serious adverse effects

  • Decrease in white blood cell count (agranulocytosis)
  • Neuroleptic Malignant Syndrome (NMS)
  • Sudden cardiac death (heart attack)
  • Torsades de pointes (serious heart arrhythmia)

Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics.

 Drug Interaction

Medications for allergies (e.g., Benadryl [diphenhydramine], certain medications for sleep (e.g., lorazepam, zopiclone), certain medications for pain (e.g., fentanyl), Antiparkinson medications.

References

  1. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1019–. ISBN 978-3-88763-075-1.
  2. ^ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 272–. ISBN 978-94-011-4439-1.
  3. ^ [www.drugs.com]
  4. ^ "Thioproperazine - Oral". Retrieved 2018-09-16.
  5. ^ "Thioproperazine". www.drugbank.ca. Retrieved 2018-09-16.
  6. ^ "Schizophrenia Society of Ontario - Majeptil (thioproperazine)". www.schizophrenia.on.ca. Retrieved 2018-09-16.