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Talastine

Talastine
Talastine.png
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H21N3O
Molar mass307.39 g/mol g·mol−1
3D model (JSmol)
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Talastine (trade name Ahanon) is an antihistamine.[1]

Synthesis

The amide proton from 4-Benzylphalazone is abstracted with KOH, which is then alkylated with diethylaminoethyl chloride.[2][3]

References

  1. ^ Richter G, Kühn E (1990). "[Talastine (Ahanon) as a cause of allergic drug exanthema]". Dermatologische Monatschrift (in German). 176 (2–3): 111–3. PMID 1973126.
  2. ^ DE 1046625, Engelbrecht, et al., issued 1958, assigned to VEB Deutsches Hydrierwerk Rodleben 
  3. ^ US 3017411, Engelbrecht, et al., issued 1962, assigned to VEB Deutsches Hydrierwerk Rodleben 

External links