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TAS2R10

TAS2R10
Identifiers
AliasesTAS2R10, T2R10, TRB2, taste 2 receptor member 10
External IDsOMIM: 604791 MGI: 2681218 HomoloGene: 128355 GeneCards: TAS2R10
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for TAS2R10
Genomic location for TAS2R10
Band12p13.2Start10,825,317 bp[1]
End10,826,358 bp[1]
RNA expression pattern
PBB GE TAS2R10 221397 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_023921

NM_207019

RefSeq (protein)

NP_076410

NP_996902

Location (UCSC)Chr 12: 10.83 – 10.83 MbChr 6: 131.69 – 131.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.[5][6][7]

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.[7]

TAS2R10 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation.[8]

See also

References

  1. ^ a b c ENSG00000121318, ENSG00000277238 GRCh38: Ensembl release 89: ENSG00000272805, ENSG00000121318, ENSG00000277238 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063478 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
  6. ^ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.
  7. ^ a b "Entrez Gene: TAS2R10 taste receptor, type 2, member 10".
  8. ^ Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction". Nat. Med. 16 (11): 1299–304. doi:10.1038/nm.2237. PMC 3066567. PMID 20972434.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.