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Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene. In humans, TAAR8 is the only trace amine-associated receptor that is known to be Gi/o-coupled.
In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors.
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]
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- ^ a b "Entrez Gene: TAAR8 trace amine associated receptor 8".
- ^ Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, et al. (November 2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile". International Journal of Molecular Sciences. 15 (11): 20638–55. doi:10.3390/ijms151120638. PMC 4264187. PMID 25391046.
- ^ Izquierdo C, Gómez-Tamayo JC, Nebel JC, Pardo L, Gonzalez A (January 2018). "Identifying human diamine sensors for death related putrescine and cadaverine molecules". PLoS Computational Biology. 14 (1): e1005945. doi:10.1371/journal.pcbi.1005945. PMC 5783396. PMID 29324768.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.