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The Sepsis Six is the name given to a bundle of medical therapies designed to reduce the mortality of patients with sepsis. The Sepsis Six was developed in 2006 by a group of physicians and nurses (Daniels, Nutbeam, Laver) working on Survive Sepsis – an educational programme to raise awareness and improve the treatment of patients with sepsis.
Survive Sepsis' training programme was based around the Surviving Sepsis Campaign  guidelines and became the official educational package of both the Surviving Sepsis Campaign and the UK Sepsis Trust.
Sepsis six 1. Administer 100% O2 2. Complete blood gases to know what antibiotics to use 3. Administer IV antibiotics 4. Administer IV fluids 5. Check lactate levels 6. Insert catheter and monitor ins/outs fluids The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis.