This page uses content from Wikipedia and is licensed under CC BY-SA.

Sepsis Six

The Sepsis Six is the name given to a bundle of medical therapies designed to reduce the mortality of patients with sepsis. The Sepsis Six was developed in 2006 by a group of physicians and nurses (Daniels, Nutbeam, Laver) working on Survive Sepsis – an educational programme to raise awareness and improve the treatment of patients with sepsis.

Survive Sepsis' training programme was based around the Surviving Sepsis Campaign [1] guidelines and became the official educational package of both the Surviving Sepsis Campaign and the UK Sepsis Trust.[2]

Sepsis six 1. Administer 100% O2 2. Complete blood gases to know what antibiotics to use 3. Administer IV antibiotics 4. Administer IV fluids 5. Check lactate levels 6. Insert catheter and monitor ins/outs fluids The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis.

  1. Titrate oxygen to a saturation target of 94%
  2. Take blood cultures.
  3. Administer empiric intravenous antibiotics.
  4. Measure serum lactate and send full blood count.
  5. Start intravenous fluid resuscitation.
  6. Commence accurate urine output measurement.

Many centres throughout the world have since adopted the Sepsis Six, which has been associated with decreased mortality, decreased length of stay in hospital, and fewer intensive care bed days.[3]


  1. ^ Dellinger RP, Levy MM, Carlet JM, et al. (January 2008). "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008". Intensive Care Med 34 (1): 17–60
  2. ^ "Home « The UK Sepsis Trust The UK Sepsis Trust". Retrieved 2014-04-22. 
  3. ^ Daniels, Ron; Nutbeam, Tim; McNamara, Georgina; Galvin, Clare (2011). "The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study". Emergency medicine journal: EMJ. 28 (6): 507–512. doi:10.1136/emj.2010.095067. ISSN 1472-0213. PMID 21036796.