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Sepsis Six

The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with sepsis.

Drawn from international guidelines that emerged out of the Surviving Sepsis Campaign [1] the Sepsis Six was developed by The UK Sepsis Trust.[2] (Daniels, Nutbeam, Laver) in 2006 as a practical tool to help healthcare professionals deliver the basics of care rapidly and reliably.

In 2011, The UK Sepsis Trust published evidence that use of the Sepsis Six was linked to a 50% reduction in mortality, a decreased length of stay in hospital, and fewer intensive care days.[3] – findings that have since been replicated around the world.

The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis:

  1. Titrate oxygen to a saturation target of 94%
  2. Take blood cultures and consider source control
  3. Administer empiric intravenous antibiotics
  4. Measure serial serum lactates
  5. Start intravenous fluid resuscitation
  6. Commence accurate urine output measurement.


  1. ^ Dellinger RP, Levy MM, Carlet JM, et al. (January 2008). "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008". Intensive Care Med 34 (1): 17–60
  2. ^ "Home « The UK Sepsis Trust The UK Sepsis Trust". Retrieved 2014-04-22.
  3. ^ Daniels, Ron; Nutbeam, Tim; McNamara, Georgina; Galvin, Clare (2011). "The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study". Emergency Medicine Journal. 28 (6): 507–512. doi:10.1136/emj.2010.095067. ISSN 1472-0213. PMID 21036796.