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Seoul orthohantavirus

Seoul orthohantavirus
Virus classification e
(unranked): Virus
Realm: Riboviria
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Subfamily: Mammantavirinae
Genus: Orthohantavirus
Seoul orthohantavirus

Seoul orthohantavirus (SEOV) is a member of the Orthohantavirus family of rodent-borne viruses and can cause Hantavirus hemorrhagic fever with renal syndrome.[1][2]

Seoul virus is carried by rats. Rats are immune to the virus, but humans can be infected through exposure to infectious body fluids (blood, saliva, urine), exposure to aerosolized rat feces, or bites from infected rats.[1] There is no evidence of human-to-human transmission of Seoul orthohantavirus.[3]

Seoul orthohantavirus was first described by Dr. Lee Ho-Wang (Ho-Wang Lee), a Korean virologist. It was originally thought that hemorrhagic fever was caused by contact with field mice (Genus Apodemus), but Dr. Lee found that it could also be caused by contact with brown or Norway rats (Rattus norvegicus). As the infection was first found in an apartment in Seoul, the virus was named "Seoul Virus".[citation needed]


Most human infections are recorded in Asia.[3] Human infections account for ~25% of cases of hemorrhagic fever with renal syndrome in Asia.[4]

As of 2015 the virus has been found in wild rats in the Netherlands, and in both rodents and humans in England, Wales, France, Belgium, and Sweden.[1] Rats in New York City are also known reservoirs.[5]

An outbreak of Seoul orthohantavirus infected eleven people in the U.S. states of Illinois, Indiana and Wisconsin from December 2016 to February 2017. Individuals who operated a home-based rat-breeding facility in Wisconsin became ill and were hospitalized. The ill individuals had purchased rats from animal suppliers in Wisconsin and Illinois. Investigators traced the infection to two Illinois ratteries and identified six additional people who tested positive for Seoul virus. All these individuals recovered. Further investigation by the Centers for Disease Control and Prevention revealed that potentially infected rodents may have traveled to the states of Alabama, Arkansas, Colorado, Illinois, Indiana, Iowa, Louisiana, Michigan, Minnesota, Missouri, North Dakota, South Carolina, Tennessee, Utah, and Wisconsin.[6][3] Cases were also reported in Ontario in February 2016.[7]

Clinical features

The patient will develop high grade fever, sweating, chills, abdominal pain, joint pain, red eye, nausea, vomiting, one or multiple rash(es) and/or a headache.

The symptoms can appear quickly, the patient will suffer from severe symptoms which may lead to death. To prevent from contracting this virus, avoid contact with wild rats and only adopt pet rats from renown sources who have tested their rats by serology in order to confirm their colony does not carry this virus. Proof of testing should be public and offered to anyone who asks for it.

See also


  1. ^ a b c Goeijenbier M; et al. (May 2015). "Seoul hantavirus in brown rats in the Netherlands: implications for physicians—Epidemiology, clinical aspects, treatment and diagnostics". Neth. J. Med. 73 (4): 155–60. PMID 25968286.
  2. ^ US Centers for Disease Control. Virology, Hantaviruses Page last reviewed: August 29, 2012.
  3. ^ a b c US Centers for Disease Control. Multi-state Outbreak of Seoul Virus Updated January 19, 2017.
  4. ^ Yao LS, Qin CF, Pu Y, Zhang XL, Liu YX, Liu Y, Cao XM, Deng YQ, Wang J, Hu KX, Xu BL (2012). "Complete genome sequence of Seoul virus isolated from Rattus norvegicus in the Democratic People's Republic of Korea". J. Virol. 86 (24): 13853. doi:10.1128/JVI.02668-12. PMC 3503101. PMID 23166256.
  5. ^ Firth, C (2014). "Detection of Zoonotic Pathogens and Characterization of Novel Viruses Carried by Commensal Rattus norvegicus in New York City". mBio. 5 (5): e01933–14. doi:10.1128/mBio.01933-14. PMC 4205793. PMID 25316698.
  6. ^ "Multi-state Outbreak of Seoul Virus | Hantavirus | DHCPP | CDC". Retrieved 2017-02-14.
  7. ^ "3 people in Ontario contract Seoul virus spread by rats". CBC News. The Canadian Press. 1 March 2017. Retrieved 4 March 2017.