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SLC45A4

SLC45A4
Identifiers
AliasesSLC45A4, solute carrier family 45 member 4
External IDsMGI: 2146236 HomoloGene: 69908 GeneCards: SLC45A4
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for SLC45A4
Genomic location for SLC45A4
Band8q24.3Start141,207,166 bp[1]
End141,308,305 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080431
NM_001286646
NM_001286648

NM_001033219
NM_001168255
NM_001357747

RefSeq (protein)

NP_001073900
NP_001273575
NP_001273577

NP_001028391
NP_001161727
NP_001344676

Location (UCSC)Chr 8: 141.21 – 141.31 MbChr 15: 73.58 – 73.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SLC45A4 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide,sucrose, as well simple sugars such as glucose and fructose (ii) perform secondary active transport in a proton-dependent manner.[5]

It is associated with sugar transport in the spermatozoa.[6] Additionally, it has been itdentified as a necessary component in the cell death caused of the compound paraquat.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000022567 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079020 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O (December 2014). "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae". The Biochemical Journal. 464 (2): 193–201. doi:10.1042/BJ20140572. PMID 25164149.
  6. ^ Vitavska O, Wieczorek H (November 2017). "+/sugar cotransporter in mammalian spermatozoa". Pflügers Archiv. 469 (11): 1433–1442. doi:10.1007/s00424-017-2024-9. PMC 5629229. PMID 28689241.
  7. ^ Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, et al. (December 2017). "A CRISPR screen identifies a pathway required for paraquat-induced cell death". Nature Chemical Biology. 13 (12): 1274–1279. doi:10.1038/nchembio.2499. PMC 5698099. PMID 29058724.