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AliasesSLC23A1, SLC23A2, SVCT1, YSPL3, solute carrier family 23 member 1
External IDsOMIM: 603790 MGI: 1341903 HomoloGene: 40769 GeneCards: SLC23A1
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SLC23A1
Genomic location for SLC23A1
Band5q31.2Start139,367,196 bp[1]
End139,384,553 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 5: 139.37 – 139.38 MbChr 18: 35.61 – 35.63 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.[5][6][7]


The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.[7]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170482 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024354 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (November 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochimica et Biophysica Acta. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.
  6. ^ Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (May 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. doi:10.1038/19986. PMID 10331392.
  7. ^ a b "Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1".

Further reading

  • Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells". Molecular Membrane Biology. 18 (1): 87–95. doi:10.1080/09687680110033774. PMID 11396616.
  • Hogue DL, Ling V (July 1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals". Genomics. 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.
  • Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (September 1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function". Biochemical and Biophysical Research Communications. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.
  • Wang H, Dutta B, Huang W, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (November 1999). "Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant". Biochimica et Biophysica Acta. 1461 (1): 1–9. doi:10.1016/S0005-2736(99)00182-0. PMID 10556483.
  • Daruwala R, Song J, Koh WS, Rumsey SC, Levine M (November 1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2". FEBS Letters. 460 (3): 480–4. doi:10.1016/S0014-5793(99)01393-9. PMID 10556521.
  • Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (January 2000). "Human vitamin C (L-ascorbic acid) transporter SVCT1". Biochemical and Biophysical Research Communications. 267 (2): 488–94. doi:10.1006/bbrc.1999.1929. PMID 10631088.
  • Erichsen HC, Eck P, Levine M, Chanock S (October 2001). "Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2)". The Journal of Nutrition. 131 (10): 2623–7. doi:10.1093/jn/131.10.2623. PMID 11584081.
  • Hediger MA (May 2002). "New view at C". Nature Medicine. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580.
  • Maulén NP, Henríquez EA, Kempe S, Cárcamo JG, Schmid-Kotsas A, Bachem M, Grünert A, Bustamante ME, Nualart F, Vera JC (March 2003). "Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells". The Journal of Biological Chemistry. 278 (11): 9035–41. doi:10.1074/jbc.M205119200. PMID 12381735.
  • Liang WJ, Johnson D, Ma LS, Jarvis SM, Wei-Jun L (December 2002). "Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected]". American Journal of Physiology. Cell Physiology. 283 (6): C1696–704. doi:10.1152/ajpcell.00461.2001. PMID 12388072.
  • Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM (August 2005). "Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells". Biochemical and Biophysical Research Communications. 334 (1): 150–6. doi:10.1016/j.bbrc.2005.06.069. PMID 15993839.
  • Erichsen HC, Engel SA, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, Olshan AF, Chanock SJ (February 2006). "Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery" (PDF). American Journal of Epidemiology. 163 (3): 245–54. doi:10.1093/aje/kwj035. PMID 16357110.
  • Kang JS, Kim HN, Jung DJ, Kim JE, Mun GH, Kim YS, Cho D, Shin DH, Hwang YI, Lee WJ (March 2007). "Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane". The Journal of Investigative Dermatology. 127 (3): 698–706. doi:10.1038/sj.jid.5700572. PMID 17008880.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.