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SCN4B

SCN4B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDsOMIM: 608256 MGI: 2687406 HomoloGene: 18384 GeneCards: SCN4B
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SCN4B
Genomic location for SCN4B
Band11q23.3Start118,133,377 bp[1]
End118,152,888 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142348
NM_001142349
NM_174934

NM_001013390

RefSeq (protein)

NP_001135820
NP_001135821
NP_777594

NP_001013408

Location (UCSC)Chr 11: 118.13 – 118.15 MbChr 9: 45.14 – 45.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels.[5] The protein is encoded by the SCN4B gene.[6] Mutations in the SCN4B are associated with long QT syndrome.[7]

SCN4B might additionally function as a cell adhesion molecule.[8][9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177098 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046480 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.
  6. ^ "Entrez Gene: sodium channel".
  7. ^ Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
  8. ^ Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.
  9. ^ Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q8IWT1 (Human Sodium channel subunit beta-4 (SCN4B)) at the PDBe-KB.