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The rubiscolins are a group of opioid peptides that are formed during digestion of the ribulose bisphosphate carboxylase/oxygenase (Rubisco) protein from spinach leaves.[1] These peptides have much in common with the better-known gluten exorphins.

Types of Rubiscolin

There are 2 known rubiscolins with known structure:


  • Structure: H-Tyr-Pro-Leu-Asp-Leu-OH


  • Function: can have an anxiolytic effect via activation of sigma1 and dopamine D1 receptors.[2]
  • Structure: H-Tyr-Pro-Leu-Asp-Leu-Phe-OH


  1. ^ Yang, Shuzhang; Yunden, Jinsmaa; Sonoda, Soushi; Doyama, Naomi; Lipkowski, Andrzej W; Kawamura, Yukio; Yoshikawa, Masaaki (2001). "Rubiscolin, a δ selective opioid peptide derived from plant Rubisco". FEBS Letters. 509 (2): 213–217. doi:10.1016/S0014-5793(01)03042-3.
  2. ^ Hirata, H; Sonoda, S; Agui, S; Yoshida, M; Ohinata, K; Yoshikawa, M (2007). "Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors". Peptides. 28 (10): 1998–2003. doi:10.1016/j.peptides.2007.07.024. PMID 17766012.

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