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Ricasetron Clinical data ATC code Identifiers
endo- N-(8-Methyl-8-azabicyclo[3.2.1]oct-3yl)-2,3-dihydro-3,3-dimethyl-indole-1-carboxamide CAS Number PubChem CID IUPHAR/BPS ChemSpider UNII ChEMBL Chemical and physical data Formula C 19 H 27 N 3 O Molar mass 313.436 g/mol g·mol −1 3D model ( JSmol)
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Ricasetron ( BRL-46470) is a drug which acts as a selective antagonist at the serotonin 5-HT 3 receptor. It has  antiemetic effects as with other 5-HT 3 antagonists, and also has  anxiolytic effects significantly stronger than other related drugs, and with less side effects than  benzodiazepine anxiolytics.  However, it has never been developed for medical use.
Newberry NR, Watkins CJ, Sprosen TS, Blackburn TP, Grahame-Smith DG, Leslie RA (August 1993). "BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors". Neuropharmacology. 32 (8): 729–35. doi: 10.1016/0028-3908(93)90180-B. PMID 8413836.
Bermudez J, Sanger GJ (June 1994). "Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets". The Journal of Pharmacy and Pharmacology. 46 (6): 520–1. doi: 10.1111/j.2042-7158.1994.tb03843.x. PMID 7932054.
Blackburn TP, Baxter GS, Kennett GA, King FD, Piper DC, Sanger GJ, Thomas DR, Upton N, Wood MD (1993). "BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties". Psychopharmacology. 110 (3): 257–64. doi: 10.1007/BF02251279. PMID 7831418.
Link CG, Leigh TJ, Dennison JK (April 1993). "The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG". British Journal of Clinical Pharmacology. 35 (4): 395–9. doi: 10.1111/j.1365-2125.1993.tb04156.x. PMC . 1381550 PMID 8485019.
de Souza Silva M, Guimarães FS, Graeff FG, Tomaz C (December 1993). "Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam". Behavioural Brain Research. 59 (1–2): 141–5. doi: 10.1016/0166-4328(93)90160-R. PMID 8155281.