Quingestanol acetate Clinical data Trade names Demovis, Pilomin, others Other names W-4540; Norethisterone acetate 3-cyclopentyl enol ether; 17α-Ethynyl-19-nortestosterone acetate 3-cyclopentyl enol ether; ENTACP; (17β)-3-(Cyclopentyloxy)-17-ethynylestra-3,5-dien-17-yl acetate Routes of administration By mouth Drug class Progestogen; Progestin; Progestogen ester ATC code Legal status Legal status
In general: ℞ (Prescription only) Identifiers
[(8 R,9 S,10 R,13 S,14 S,17 R)-3-cyclopentyloxy-17-ethynyl-13-methyl-2,7,8,9,10,11,12,14,15,16-decahydro-1 H-cyclopenta[ a]phenanthren-17-yl] acetate CAS Number PubChem CID ChemSpider CompTox Dashboard ( EPA) ECHA InfoCard 100.019.163 Chemical and physical data Formula C 27 H 36 O 3 Molar mass 408.573 g/mol g·mol −1 3D model ( JSmol)
Quingestanol acetate, sold under the brand names Demovis and Pilomin among others, is a progestin medication which was used in birth control pills but is no longer marketed. It is taken  by mouth.  
Quingestanol acetate is a progestin, or a
synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.   It has weak  androgenic and estrogenic activity and no other important hormonal activity.   The medication is a  prodrug of norethisterone in the body, with quingestanol and norethisterone acetate occurring as intermediates. 
Quingestanol acetate was
patented in 1963 and was introduced for medical use in 1972.  It was marketed in  Italy.
Quingestanol acetate was used as an
oral, once-a-month, or postcoital hormonal contraceptive.  
Quingestanol acetate is a
progestogen, and also has weak androgenic and estrogenic activity.   It is a  prodrug of norethisterone, with both quingestanol and norethisterone acetate serving as intermediates in the transformation.  Unlike  penmesterol ( methyltestosterone 3-cyclopentyl enol ether) and quinestrol ( ethinylestradiol 3-cyclopentyl ether), quingestanol acetate is not stored in fat and does not have a prolonged duration of action.
Quingestanol acetate, also known as norethisterone 17β-acetate 3-cyclopentyl enol ether or as 17α-ethynyl-19-nortestosterone 17β-acetate 3-cyclopentyl enol ether (ENTACP), as well as 3-(cyclopentyloxy)-17α-ethynylestra-3,5-dien-17β-yl acetate, is a
synthetic estrane steroid and a derivative of testosterone. It is specifically a derivative of  19-nortestosterone and 17α-ethynyltestosterone, or of norethisterone (17α-ethynyl-19-nortestosterone), in which a cyclopentyl enol ether group has been attached at the C3 position and an acetate ester has been attached at the C17β position. Quingestanol acetate is the C17β  acetate ester of quingestanol (norethisterone 3-cyclopentyl enol ether).
Quingestanol acetate was patented in 1963
and marketed in  Italy in 1972. 
Society and culture
Quingestanol acetate is the generic name of the drug and its and INN . USAN
Quingestanol acetate was marketed under the brand names Demovis, Pilomin, Riglovis, and Unovis.
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Donde UM, Virkar KD (June 1975). "Biochemical studies with once-a-month contraceptive pill containing quinestrol-quingestanol acetate". Contraception. 11 (6): 681–8. doi: 10.1016/0010-7824(75)90065-7. PMID 1137940.
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Di Carlo FJ, Loo JC, Aceto T, Zuleski FR, Barr WH (1974). "Quingestanol acetate metabolism in women". Pharmacology. 11 (5): 287–303. doi: 10.1159/000136501. PMID 4853997.
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