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Pyroglutamylated RFamide peptide receptor

QRFPR
Identifiers
AliasesQRFPR, AQ27, GPR103, SP9155, pyroglutamylated RFamide peptide receptor
External IDsOMIM: 606925 MGI: 2677633 HomoloGene: 18865 GeneCards: QRFPR
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for QRFPR
Genomic location for QRFPR
Band4q27Start121,328,642 bp[1]
End121,381,059 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198179

NM_198192

RefSeq (protein)

NP_937822

NP_937835

Location (UCSC)Chr 4: 121.33 – 121.38 MbChr 3: 36.18 – 36.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.[5][6]

Function

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[5]

A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[7] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186867 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058400 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GPR103 G protein-coupled receptor 103".
  6. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
  7. ^ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
  8. ^ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.

Further reading

External links

  • "Peptide P518 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.