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Prokineticin receptor 2

PROKR2
Identifiers
AliasesPROKR2, GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3, prokineticin receptor 2
External IDsOMIM: 607123 MGI: 2181363 HomoloGene: 16368 GeneCards: PROKR2
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PROKR2
Genomic location for PROKR2
Band20p12.3Start5,302,040 bp[1]
End5,314,369 bp[1]
RNA expression pattern
PBB GE PROKR2 gnf1h10315 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144773

NM_144944

RefSeq (protein)

NP_658986

NP_659193

Location (UCSC)Chr 20: 5.3 – 5.31 MbChr 2: 132.34 – 132.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prokineticin receptor 2 (PKR2), is a G protein-coupled receptor encoded by the PROKR2 gene in humans.[5]

Function

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[5]

Mutations in the PROKR2 (also known as KAL3) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101292 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050558 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PROKR2 prokineticin receptor 2".
  6. ^ Narula HS, Carlson HE (November 2014). "Gynaecomastia--pathophysiology, diagnosis and treatment". Nature Reviews. Endocrinology. 10 (11): 684–98. doi:10.1038/nrendo.2014.139. PMID 25112235.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.