|Poly drug use|
Poly drug use refers to the use of two or more psychoactive drugs in combination to achieve a particular effect. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.
A caffeinated alcoholic drink is an alcoholic beverage that also contains caffeine, often in the form of an energy drink. The combination can result in reduced subjective alcohol intoxication but does not reduce in lowered objective intoxication.
Ayahuasca is a beverage that combines monoamine oxidase inhibitors (MAOIs) and N,N-Dimethyltryptamine (DMT). DMT is normally inactive when taken by mouth due to being broken down by monoamine oxidase in the stomach, but the MAOIs block the enzyme action and allow the DMT to travel to the brain where it has a psychedelic drug effect.
Pharmahuasca is like ayahuasca except that the DMT and MAOIs are mixed as pharmaceutical chemicals instead of plant extracts.
A speedball is a mixture of cocaine and heroin. The combination is used because it is believed to provide more euphoria while having each drug balance out negative side effects from each other. The combination has a higher risk of overdose than of either drug alone.
|Drug 1||Drug 2||Drug 3||Poly drug name||Intoxication name||Comment|
|Any drug||Nicotine||Cooler||A cigarette laced with a drug|
|Any depressant||Any stimulant||Over and under|
|Any pharmaceutical||Any pharmaceutical||Pharming|
|Alcohol||Caffeine||Caffeinated alcoholic drink|
|Alcohol||Cannabis||Herb and Al||Cross fading|
|Alcohol||Cocaine||Snow-coning||Metabolized into a cocaethylene|
|Banisteriopsis caapi||β-Carbolines containing plants (eg Peagnum harmala)||Ayahuasca, changa|
|Barbiturates||Alcohol||Used to be common, when Barbiturates were more readily available|
|Cannabis||Any drug||Amp joint||Marihuana cigarette laced with some form of narcotic|
|Cannabis||Crack-cocaine||Crack weed (less known: champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, splitting, thirty eight, turbo, wollie, yeola)||Cocoa puffs|
|Cannabis||Heroin||Atom bomb, stuff|
|Cannabis||Heroin or opium||A-bomb|
|Cannabis||PCP||Killer weed (less known: clickums, donk, dust blunt, illies, illing, leak, love leaf, lovelies, parsley, zoom)|
|Cannabis||Nicotine||Blunt, spliff||Stoned||A rolled marijuana cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with marijuana. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.|
|Cocaine||Heroin||Snowball, murder one, whiz bang||Snowballing|
|Cocaine||Heroin||Nicotine||flamethrower, primos||Cigarette laced with cocaine and heroin|
|Cocaine||Heroin or morphine||Speedball, powerball||Speedballing, powerballing||Speedballing, powerballing is often used to describe intravenous use. The term can also be applied to use of pharmaceutical opioids, benzodiazepines or barbiturates along with stimulants.|
|Cocaine||Ketamine||CK1, Calvin Klein, Cable|
|Cocaine||LSD||Cracid (or outer limits)|
|Cocaine||Morphine||C & M|
|Codeine||Glutethimide||Pancakes and syrups||Combination of glutethimide and codeine cough syrup|
|Crack-cocaine||Benzocaine||Fire||Crack cut with benzocaine|
|Crack-cocaine||Heroin||Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar|
|Crack-cocaine||PCP||Nicotine||Ozone||PCP and crack cigarette|
|Crack-cocaine||PCP||Missile basing, P-funk, space basing, spaceball, space cadet, space dust, tragic magic|
|Crack-cocaine||Nicotine||Coolie, crimmie, woolas||A cigarette laced with crack|
|DMT||Salvia Divinorum||Sally and Dimitri|
|DXM||Psilocybin or psilocybin mushroom||Cherry-bombing|
|Hashish||Belladonna||Alamout Black Hash||Mixed|
|Hashish||LSD||Royal Temple Ball||The hashish is mixed with LSD and rolled into a ball intended for oral use, because LSD cannot be smoked.|
|Heroin||Morphine||New Jack swing|
|LSD||Marijuana||Amphetamine||Hippie heart attack|
|LSD||Psilocybin or psilocybin mushroom||God's flesh|
|LSD||DMT||Cosmo flip||Cosmo flipping|
|MDMA||2C-B||Nexus flip, honey flip, pancake flip||Nexus flipping, honey flipping, pancake flipping|
|MDMA||2C-E||Sparkle flip||Sparkle flipping|
|MDMA||2C-I||Science flip||Science flipping|
|MDMA||2C-T-7||Lucky flip||Lucky flipping|
|MDMA||Alcohol||Tipsy flip||Tipsy flipping|
|MDMA||Cannabis||Stoner flip||Stoner flipping|
|MDMA||Cocaine||Sugar flip||Sugar flipping|
|MDMA||Cocaine||LSD||Candy-flip on a string||Candy-flipping on a string|
|MDMA||DMT||Shaman flip, time flip||Shaman flipping, time flipping|
|MDMA||DXM||Robo flip||Robo flipping|
|MDMA||GHB||Gamma flip||Gamma flipping|
|MDMA||Ketamine||Kitty flip||Kitty flipping|
|MDMA||Ketamine||GHB||EKG. The "E" is for Ecstasy.|
|MDMA||LSD||Candy flip||Candy flipping|
|MDMA||LSD||Psilocybin or psilocybin mushroom||Jedi flip, twilight flip||Jedi flipping, twilight flipping|
|MDMA||MDEA||Adam and Eve|
|MDMA||Mescaline or psychoactive cactus||Love flip||Love flipping|
|MDMA||Methadone||Chocolate flip||Chocolate flipping|
|MDMA||Methamphetamine||Trailer flip||Trailer flipping|
|MDMA||Opiates||Poppy flip||Poppy flipping|
|MDMA||PCP||Elephant flip||Elephant flipping|
|MDMA||Psilocybin or psilocybin mushroom||Hippy flip, flower flip, ethno flip||Hippy flipping, flower flipping, ethno flipping|
|MDMA||Psilocybin or psilocybin mushroom||Cocaine||Flower flip on a string, hippie flip on a string, ethno flip on a string||Flower flipping on a string, hippie flipping on a string, ethno flipping on a string|
|MDMA||Sildenafil||Sextasy (or hammerheading)|
|MDMA||5-MeO-DiPT||Foxy flip||Foxy flipping|
Poly drug use often carries with it more risk than use of a single drug, due to an increase in side effects, and drug synergy. The potentiating effect of one drug on another is sometimes considerable and here the licit drugs and medicines – such as alcohol, nicotine and antidepressants – have to be considered in conjunction with the controlled psychoactive substances. The risk level will depend on the dosage level of both substances. If the drugs taken are illegal, they have a chance of being mixed (also known as "cutting") with other substances which dealers are reported to do to increase the perceived quantity when selling to others to increase their returns. This is particularly common with powdered drugs such as cocaine or MDMA which can be mixed with relative ease by adding another white powdery substance to the drug. This cumulative effect can lead to further unintended harm to health dependent on what is being covertly added. Concerns also exist about a number of pharmacological pairings: alcohol and cocaine increase cardiovascular toxicity; alcohol or depressant drugs, when taken with opioids, lead to an increased risk of overdose; and opioids or cocaine taken with ecstasy or amphetamines also result in additional acute toxicity. Benzodiazepines can cause death when mixed with other CNS depressants such as opioids, alcohol, or barbiturates.
Within the general concept of multiple drug use, several specific meanings of the term must be considered. At one extreme is planned use, where the effects of more than one drug are taken for a desired effect. Another type is when other drugs are used to counteract the negative side effects of a different drug (e.g. depressants are used to counteract anxiety and restlessness from taking stimulants). On the other hand, the use of several substances in an intensive and chaotic way, simultaneously or consecutively, in many cases each drug substituting for another according to availability.
The phenomenon is the subject of established academic literature.
A study among treatment admissions found that it is more common for younger people to report polydrug drug use.