Treatment of gait disorders associated with Parkinson's disease (no related cause) and other forms of parkinsonism
The drug has been shown to enhance working memory capacities in normal aging adults.
In age-related memory impairment, it has a positive effect on psychophysiological state of elderly people, improving memory and attention and increasing the velocity of psychomotor reactions and lability of nervous processes.
It enhances cognitive skill learning in healthy older adults.
Administration of piribedil should be initiated with one sustained-release tablet (50 mg) daily during the first week. Dosage should then be gradually increased every week until achieving the optimal therapeutic dose:
as monotherapy: three to five tablets in three to five doses daily.
in combination with L-DOPA therapy: one to three tablets daily.
One tablet daily at the end of the main meal. In severe cases: two tablets daily in two doses.
At very high doses, piribedil has an emetic action on the chemoreceptor trigger zone (CTZ). Tablets will thus be rapidly rejected, which explains why no data are currently available concerning the risk of overdosage.
^Gierski, F.; Peretti, C.; Ergis, A. (30 January 2007). "Effects of the dopamine agonist piribedil on prefrontal temporal cortical network function in normal aging as assessed by verbal fluency". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31 (1): 262–268. doi:10.1016/j.pnpbp.2006.06.017. PMID16876301.
^Bochkarev, V. K.; Faĭzulloev, A. Z.; Avedisova, A. S. (2005). "Efficacy of pronoran in age-related memory impairment". Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova. 105 (2): 46–50. PMID15792142.
^Peretti, C. S.; Gierski, F.; Harrois, S. (November 2004). "Cognitive skill learning in healthy older adults after 2 months of double-blind treatment with piribedil". Psychopharmacology. 176 (2): 176–182. doi:10.1007/s00213-004-1869-8. PMID15138753.