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Pinoxepin

Pinoxepin
Pinoxepin.svg
Clinical data
SynonymsPinoxepine; P-5227
Routes of
administration
Oral
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC23H27ClN2O2
Molar mass398.93 g·mol−1
3D model (JSmol)

Pinoxepin (INN; developmental code name P-5227; pinoxepin hydrochloride (USAN)) is an antipsychotic of the tricyclic group with a dibenzoxepin ring system which was developed in the 1960s but was never marketed.[1][2][3][4][5] It was found in clinical trials to have effectiveness in the treatment of schizophrenia similar to that of chlorpromazine and thioridazine.[4] The drug has marked sedative effects but causes relatively mild extrapyramidal symptoms.[2][4]

References

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 984–. ISBN 978-1-4757-2085-3.
  2. ^ a b Annual Reports in Medicinal Chemistry. Academic Press. 1 January 1967. pp. 2–. ISBN 978-0-08-058346-4.
  3. ^ Maxwell Gordon (2 December 2012). Psychopharmacological Agents. Elsevier Science. pp. 102–. ISBN 978-0-323-15128-3.
  4. ^ a b c Leslie Iversen (6 December 2012). Handbook of Psychopharmacology: Volume 10: Neoroleptics and Schizophrenia. Springer Science & Business Media. pp. 200–. ISBN 978-1-4613-4042-3.
  5. ^ Abel Lajtha (11 November 2013). Alterations of Metabolites in the Nervous System. Springer Science & Business Media. pp. 335–. ISBN 978-1-4757-6740-7.