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Phenylbiguanide

Phenylbiguanide
1-Phenylbiguanide.svg
Legal status
Legal status
  • UN: Unscheduled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.002.726 Edit this at Wikidata
Chemical and physical data
FormulaC8H11N5
Molar mass177.211 g·mol−1
3D model (JSmol)
Melting point135–142 °C (275–288 °F)

Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system.[1] It has been found to trigger dopamine release in the nucleus accumbens of rats.[2]

Derivatives

  • Phenylbiguanide is used to make amanozine and benfosformin.[citation needed]

References

  1. ^ Higgins GA, Joharchi N, Sellers EM (March 1993). "Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats". The Journal of Pharmacology and Experimental Therapeutics. Journal of Pharmacology and Experimental Therapeutics. 264 (3): 1440–9. PMID 8450478.
  2. ^ Chen JP, van Praag HM, Gardner EL (March 1991). "Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens". Brain Research. Brain Research. 543 (2): 354–7. doi:10.1016/0006-8993(91)90050-6. PMID 1711914.