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Paxilline

Paxilline
Paxilline.png
Names
IUPAC name
(2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.164.932
MeSH Paxilline
Properties
C27H33NO4
Molar mass 435.56 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Paxilline is a potassium channel blocker. Paxilline is a toxic, tremorgenic indole alkaloid produced by Penicillium paxilli .[1] Paxilline was found to significantly extend the lifespan healthspan and mobility of C. elegans aged worms, but had no such effect on young worms. [2]

Sources and references

  1. ^ Paxilline product page from Fermentek
  2. ^ Li, Guang; Gong, Jianke; Liu, Jie; Liu, Jinzhi; Li, Huahua; Hsu, Ao-Lin; Liu, Jianfeng; Xu, X.Z. Shawn (2019). "Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend life span in C. Elegans". Science Advances. 5: eaau5041. doi:10.1126/sciadv.aau5041. PMC 6314820.