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Parathyroid hormone 2 receptor

PTH2R
Identifiers
AliasesPTH2R, PTHR2, parathyroid hormone 2 receptor
External IDsOMIM: 601469 MGI: 2180917 HomoloGene: 3701 GeneCards: PTH2R
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PTH2R
Genomic location for PTH2R
Band2q34Start208,359,714 bp[1]
End208,854,503 bp[1]
RNA expression pattern
PBB GE PTHR2 206772 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001309516
NM_005048

NM_139270

RefSeq (protein)

NP_001296445
NP_005039

NP_644676

Location (UCSC)Chr 2: 208.36 – 208.85 MbChr 1: 65.28 – 65.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene.[5]

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas.[5]

The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144407 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025946 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PTH2R parathyroid hormone 2 receptor".
  6. ^ Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D (2017). "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5". Biochemical Pharmacology. 127: 71–81. doi:10.1016/j.bcp.2016.12.013. PMC 5303546. PMID 28012961.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.