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AliasesP2RY8, P2Y8, purinergic receptor P2Y8, P2Y receptor family member 8
External IDsOMIM: 300525 HomoloGene: 65345 GeneCards: P2RY8
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for P2RY8
Genomic location for P2RY8
BandXp22.33 and Yp11.2Start1,462,581 bp[1]
End1,537,185 bp[1]
RNA expression pattern
PBB GE P2RY8 gnf1h10171 at fs.png

PBB GE P2RY8 gnf1h10172 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 1.46 – 1.54 Mbn/a
PubMed search[2]n/a
View/Edit Human

P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.[3][4]


The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.[4]

Clinical relevance

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[5]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182162 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Jun 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
  4. ^ a b "Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8".
  5. ^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.