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Available structures
PDBOrtholog search: PDBe RCSB
AliasesP2RY4, NRU, P2P, P2Y4, UNR, pyrimidinergic receptor P2Y4
External IDsOMIM: 300038 MGI: 1926594 HomoloGene: 20568 GeneCards: P2RY4
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for P2RY4
Genomic location for P2RY4
BandXq13.1Start70,258,170 bp[1]
End70,259,764 bp[1]
RNA expression pattern
PBB GE P2RY4 221466 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 70.26 – 70.26 MbChr X: 100.59 – 100.59 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.[5][6]

The product of this gene, P2Y4, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.[6]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186912 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044359 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Communi D, Pirotton S, Parmentier M, Boeynaems JM (Feb 1996). "Cloning and functional expression of a human uridine nucleotide receptor". J Biol Chem. 270 (52): 30849–52. doi:10.1074/jbc.270.52.30849. PMID 8537336.
  6. ^ a b "Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4".

Further reading

External links

  • "P2Y Receptors: P2Y4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.