|AHFS/Drugs.com||International Drug Names|
|Metabolism||Esterases in blood plasma and liver|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||308.41 g/mol g·mol−1|
|3D model (JSmol)|
Oxybuprocaine (INN), also known as benoxinate or BNX, is an ester-type local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine is sold by Novartis under the brand names Novesine or Novesin.
Safety for use in pregnancy and lactation has not been established.
When used excessively, oxybuprocaine like any other topical anesthetic used in the eye and on mucous membranes (like for example tetracaine, proxymetacaine and proparacaine) can cause irritation, hypersensitivity, anaphylaxis, irreversible corneal damage and even complete destruction of the cornea. (Excessive use means several times a day during several days or even weeks.)