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|AHFS/Drugs.com||International Drug Names|
|Metabolism||Metabolized via the liver, excreted in the Urine and Feces|
|Excretion||85% of single oral dose is eliminated with 5 days - Urine (63%) and Feces (22%)|
|Chemical and physical data|
|Molar mass||219.63 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
After passive absorption into bacterium cell, the nitro group of ornidazole is reduced to an amine group by ferrodoxin-type redox systems. The formation of redox intermediate intracellular metabolites is believed to be the key component responsible for killing microorganisms. The drug is active against anaerobic bacteria including Peptostreptococcus, Clostridium, Bacteroides fragilis, Prevotella, Porphyromonas gingivalis, and Fusobacterium as well as protozoa including Entamoeba histolytica, Trichomonas vaginalis, and Giardia lamblia.
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