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Olorinab

Olorinab
Olorinab structure.png
Clinical data
Routes of
administration
Oral
Identifiers
CAS Number
PubChem CID
KEGG
Chemical and physical data
FormulaC18H24N5O3
Molar mass358.422 g·mol−1
3D model (JSmol)

Olorinab (APD371) is a drug being developed by Arena Pharmaceuticals for the treatment of gastrointestinal pain associated with Crohn's disease and irritable bowel syndrome.[1] It acts as a potent and selective cannabinoid CB2 receptor agonist and is claimed to be orally active and peripherally selective.[2][3] Initial Phase IIa exploratory clinical trials have been successful,[4] with Phase IIb trials projected to start in 2019.[5]

See also

References

  1. ^ "Arena Pharmaceuticals Presented New Phase 2 Data for Etrasimod and Olorinab at the 14th Congress of European Crohn's and Colitis Organisation". Arena Pharmaceuticals, Inc. Retrieved 2019-04-13.
  2. ^ Han S, Thoresen L, Jung JK, Zhu X, Thatte J, Solomon M, et al. (December 2017). "Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain". ACS Medicinal Chemistry Letters. 8 (12): 1309–1313. doi:10.1021/acsmedchemlett.7b00396. PMC 5733264. PMID 29259753.
  3. ^ "Olorinab (APD371)". Arena Pharmaceuticals, Inc.
  4. ^ "Arena Pharmaceuticals Reports Positive Phase 2a Results for Olorinab in Patients with Abdominal Pain Associated with Crohn's Disease". Arena Pharmaceuticals, Inc. Retrieved 2019-04-13.
  5. ^ "18th Annual Needham Healthcare Conference". wsw.com. Retrieved 2019-04-13.