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ORG-37684

ORG-37684
Org37684 structure.png
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
Chemical and physical data
FormulaC14H19NO2
Molar mass233.305 g/mol g·mol−1
3D model (JSmol)
  (verify)

ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.[1][2] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.[3]

See also

References

  1. ^ Adams D, Duncton M (2001). "Efficient Synthesis of the 5-Ht2C Receptor Agonist, Org 37684". Synthetic Communications. 31 (13): 2029–2036. doi:10.1081/SCC-100104420.
  2. ^ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (2): 114–23. doi:10.1007/s00210-004-0951-4. PMID 15322733.
  3. ^ Schreiber R, De Vry J (April 2002). "Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 26 (3): 441–9. doi:10.1016/s0278-5846(01)00284-6. PMID 11999893.