|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||265.662 g/mol g·mol−1|
|3D model (JSmol)|
|NY (what is this?)|
ORG-12962 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes. It was developed as a potential anti-anxiety drug, but was discontinued from human trials after tests in a public speaking challenge showed that its anti-anxiety effects were accompanied by side effects such as dizziness and a "spacey" feeling, which were attributed to poor selectivity in vivo over the hallucinogenic 5-HT2A receptor.
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