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Nicotinyl alcohol

Nicotinyl alcohol
Nicotinyl alcohol.png
Clinical data
Other namesRoniacol; Roniacol tartrate; Nicotinyl tartrate;[1] Nicotinyl alcohol tartrate; Nicotinic alcohol; Pyridylcarbinol
ATC code
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.002.604 Edit this at Wikidata
Chemical and physical data
Molar mass109.126 g/mol g·mol−1
3D model (JSmol)
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Nicotinyl alcohol (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes flushing and may decrease blood pressure.[2]

It appears as a crystal that dissolves in water and alcohol with ease, also soluble in ether; melting range 147–148 ºC.[citation needed]

Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper thorax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, like arteriosclerosis obliterans,[3] Raynaud's disease,[4] thromboangiitis obliterans (Buerger's disease),[5] arterial embolism, chilblains or migraine associated with vascular spasm.

Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in symptoms related to intermittent claudication,[6] ulcer healing and others.[7]


At least a couple of uses for this agent were discovered over the years:

  1. Eniclobrate
  2. Mepiroxol
  3. Nicofibrate
  4. Pantenicate (Topanicate, MG 28362)


  1. ^ Norwood WF (1963). "Vasodilator Effects of Nicotinyl Tartrate (Roniacol Tartrate)". JAMA. 186: 1013. doi:10.1001/jama.1963.03710110065012. PMID 14066712.
  2. ^ "Ronicol Retard". Medical Dictionary Online. 2012. Archived from the original on June 14, 2011. Retrieved July 27, 2012.
  3. ^ Richter IH, Fogel M, Fabricant H (1951). "An evaluation of roniacol tartrate in arteriosclerosis obliterans". New York State Journal of Medicine. 51 (10): 1303–4. PMID 14843421.
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  5. ^ [] Page 18
  6. ^ Gillhespy, RO (1957). "Nicotinyl Alcohol Tartrate in Intermittent Claudication". British Medical Journal. 18 (2): 207–208. PMID 1974214.
  7. ^ Fisher MM, Tebrock HW (1953). "Nicotinic alcohol (roniacol) in peripheral vascular diseases and allied conditions: its use and limitations". New York State Journal of Medicine. 53 (1): 65–8. PMID 13025721.