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Structural formula of nedocromil
Space-filling model of the nedocromil molecule
Clinical data
Trade namesAlocril
Routes of
Inhalation and eye drops
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding89%
Metabolismnot metabolized
Elimination half-life~3.3 hours
Excretionexcreted unchanged
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.233.208 Edit this at Wikidata
Chemical and physical data
Molar mass371.341 g/mol g·mol−1
3D model (JSmol)

Nedocromil sodium is a medication considered as mast cell stabilizer which act to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade (although its effects in this form are far less than those in albuterol or other well-known inhaler medications) and as an eye drop under the brand name Alocril.[1][2] Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.[3] Nedocromil sodium has been shown to be effective in alleviating symptoms of allergic conjunctivitis.[4]

Nedocromil is classified as a benzopyrone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.[5]


Media related to Nedocromil at Wikimedia Commons

  1. ^ "ALOCRIL Product Information". ALLERGAN. Retrieved 17 May 2013.
  2. ^ "ALOCRIL (nedocromil sodium) solution/ drops". NIH. Retrieved 17 May 2013.
  3. ^ "Nedocromil eye drops". 2007-02-02. Retrieved 2009-08-04.
  4. ^ Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis" (PDF). Cochrane Database Syst Rev. 6: CD009566. doi:10.1002/14651858.CD009566.pub2. PMID 26028608.CS1 maint: uses authors parameter (link)
  5. ^ "Questions and Answers:Phase-Out of CFC Metered-Dose Inhalers Containing flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil". Retrieved 18 September 2014.