|Chemical and physical data|
|Molar mass||300.223 g/mol g·mol−1|
|3D model (JSmol)|
NS-2359 (GSK-372,475) is a serotonin-norepinephrine-dopamine reuptake inhibitor. It was under development by GlaxoSmithKline (GSK) as an antidepressant, but was discontinued in 2009 when phase II clinical trials turned up disappointing results and did not support further effort by the company. NS-2359 was also in clinical trials for the treatment of ADHD, phase II having been completed in 2007. A trial exploring the effect of NS-2359 on cocaine-dependent individuals is currently ongoing.
Another scientific article on NS-2359 was recently (2011) published. As can be seen from reading the abstract to the citation, the compound failed to perform in clinical trials for the treatment of depression.
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