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AliasesNPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1
External IDsOMIM: 108960 MGI: 97371 HomoloGene: 37367 GeneCards: NPR1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for NPR1
Genomic location for NPR1
Band1q21.3Start153,678,688 bp[1]
End153,693,992 bp[1]
RNA expression pattern
PBB GE NPR1 32625 at fs.png

PBB GE NPR1 204648 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 153.68 – 153.69 MbChr 3: 90.45 – 90.47 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.


NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).[5]

It is localized in the kidney[6] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.[6]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169418 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027931 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)".
  6. ^ a b BioGPS > NPR1 Retrieved Nov 2010 Archived November 27, 2010, at the Wayback Machine

Further reading

  • Pandey KN (2002). "Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments". Mol. Cell. Biochem. 230 (1–2): 61–72. doi:10.1023/A:1014240006767. PMID 11952097.
  • Lucarelli K, Iacoviello M, Dessì-Fulgheri P, et al. (2003). "[Natriuretic peptides and essential arterial hypertension]". Italian Heart Journal Supplement. 3 (11): 1085–91. PMID 12506509.
  • Pandey KN (2005). "Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A". Peptides. 26 (6): 985–1000. doi:10.1016/j.peptides.2004.12.020. PMID 15911067.
  • Garg R, Pandey KN (2005). "Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression". Peptides. 26 (6): 1009–23. doi:10.1016/j.peptides.2004.09.022. PMID 15911069.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.