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Legal status
Legal status
CAS Number
Chemical and physical data
Molar mass219.328 g·mol−1
3D model (JSmol)

N-Ethylhexedrone (also known as α-ethylaminocaprophenone, N-ethylnorhexedrone, hexen, and NEH) is a stimulant of the cathinone class.[1] N-Ethylhexedrone was first mentioned in a series of patents by Boehringer Ingelheim in the 1960s[2] which led to the development of the better-known drug methylenedioxypyrovalerone (MDPV).[3] Since the mid-2010s, N-ethylhexedrone has been sold online as a designer drug.[4][5][6] In 2018, N-ethylhexedrone was the second most common drug of the cathinone class to be identified in Drug Enforcement Administration seizures.[7]

Legal status

In the United States, N-ethylhexedrone is a Schedule I Controlled Substance.[8] N-Ethylhexedrone is illegal in Japan,[9] and Sweden.[10]

See also


  1. ^ Matsuta, Shuntaro; Katagi, Munehiro; Nishioka, Hiroshi; Kamata, Hiroe; Sasaki, Keiko; Shima, Noriaki; Kamata, Tooru; Miki, Akihiro; Tatsuno, Michiaki; Zaitsu, Kei; Tsuboi, Kento; Tsuchihashi, Hitoshi; Suzuki, Koichi (2014). "Structural characterization of cathinone-type designer drugs by EI mass spectrometry". Japanese Journal of Forensic Science and Technology (in Japanese). 19 (2): 77–89. doi:10.3408/jafst.19.77.
  2. ^ Herbert, Koeppe; Karl, Zeile; Gerhard, Ludwig (28 May 1965), Patent DE1545591 - Verfahren zur Herstellung von α-Aminoketonen mit heterocyclischer Aminogruppe (in German)
  3. ^ Kolanos, Renata; Solis, Ernesto; Sakloth, Farhana; Felice, Louis J. De; Glennon, Richard A. (18 December 2013). ""Deconstruction" of the Abused Synthetic Cathinone Methylenedioxypyrovalerone (MDPV) and an Examination of Effects at the Human Dopamine Transporter". ACS Chemical Neuroscience. 4 (12): 1524–1529. doi:10.1021/cn4001236. PMC 3867964. PMID 24116392.
  4. ^ "2-(Ethylamino)-1-phenylhexan-1-one". New Synthetic Drugs Database.
  5. ^ "Analytical Report - N-Ethylhexedrone" (PDF). European Project RESPONSE.
  6. ^ Liu, Cuimei; Jia, Wei; Li, Tao; Hua, Zhendong; Qian, Zhenhua (2017). "Identification and analytical characterization of nine synthetic cathinone derivatives N -ethylhexedrone, 4-Cl-pentedrone, 4-Cl-α -EAPP, propylone, N -ethylnorpentylone, 6-MeO-bk-MDMA, α -PiHP, 4-Cl-α -PHP, and 4-F-α -PHP". Drug Testing and Analysis. 9 (8): 1162–1171. doi:10.1002/dta.2136. PMID 27863142.
  7. ^ "Emerging Threat Report: Annual 2018" (PDF). Special Testing and Research Laboratory, Drug Enforcement Administration.
  8. ^ "Schedules of Controlled Substances: Temporary Placement of N-Ethylhexedrone, α-PHP, 4-MEAP, MPHP, PV8, and 4-Chloro-α-PVP in Schedule I". Drug Enforcement Administration.
  9. ^ "指定薬物一覧" [Designated drug list] (PDF) (in Japanese). Ministry of Health, Labour and Welfare.
  10. ^ "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" [31 new substances can be classified as drugs or health hazardous products] (in Swedish). Folkhälsomyndigheten. 21 June 2016.