Herodotus records the entire Gulf of Alexandretta as Marandynian Bay (Ancient Greek: Μυριανδρικὸς κόλπος), after Myriandrus. (Later classical geographers would subsequently name the bay after nearby Issus.) Stephanus of Byzantium also called it Marandynian gulf.
Xenophon claimed that Myriandrus was the border town between Cilicia and Syria. (Herodotus, meanwhile, placed the line further south at Ras al-Bassit in what is now Syria. Xenophon also say that it was an Emporium.
In 333 BC, Alexander the Great encamped near the city and intended to attack on the army of Darius III of Persia, but at the night a heavy tempest and storm detained him in his camp. In the end the battle took place near Issus.