The title and lyrics reference the novel Do Androids Dream of Electric Sheep? by Philip K. Dick, adapted in film as Blade Runner. The title was the slogan of the Tyrell Corporation, manufacturers of the very humaniform biological androids, or "replicants" that are the focal point of the story. "I want more life, fucker" (quoted in the lyrics) is one of the last things his creator hears when the replicant designed to be the perfect – and disposable – soldier (Rutger Hauer) finds him and is denied a reprieve from the programmed 4 year life span.
"More Human than Human" quickly became the band's highest-charting and most recognizable single in the entirety of their career. The song earned them their second Grammy nomination for Best Metal Performance in 1995. The song was named the 68th best hard rock song of all time by VH1.
The song was listed as number 4 on PopMatters' "The 10 Best Alternative Metal Singles of the 1990s" list.
The music video of "More Human than Human," the first video made for Astro-Creep: 2000, features White Zombie playing the track in a room and short clips of old home video footage of Rob, his brother, Michael Cummings (better known as Spider One of the band Powerman 5000), and a cousin at a young age. Part of the video was also shot in the halls of Framingham High School, Framingham, Massachusetts as well as on the streets of Hollywood Boulevard. It was the first video that had been completely directed by Rob alone. In 1995, he won the MTV Video Music Award for Hard Rock Video for this music video. At the time, it was Rob's favorite White Zombie music video.