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Monocarboxylate transporter 4

SLC16A3
Identifiers
AliasesSLC16A3, MCT 3, MCT 4, MCT-3, MCT-4, MCT3, MCT4, solute carrier family 16 member 3
External IDsOMIM: 603877 MGI: 1933438 HomoloGene: 37900 GeneCards: SLC16A3
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SLC16A3
Genomic location for SLC16A3
Band17q25.3Start82,228,397 bp[1]
End82,261,129 bp[1]
RNA expression pattern
PBB GE SLC16A3 202856 s at fs.png

PBB GE SLC16A3 217691 x at fs.png

PBB GE SLC16A3 202855 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001038653
NM_001038654
NM_030696

RefSeq (protein)

NP_001033742
NP_001033743
NP_109621

Location (UCSC)Chr 17: 82.23 – 82.26 MbChr 11: 120.95 – 120.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene.[5][6]

Northern and western blotting and EST database analyses showed MCT4 to be widely expressed and especially so in glycolytic tissues such as white skeletal muscle fibers, astrocytes, white blood cells, chondrocytes, and some mammalian cell lines. Because of this, it has been proposed that the properties of MCT4 might be especially appropriate for export of lactate derived from glycolysis. MCT4 exhibits a lower affinity for most substrates and inhibitors than MCT1, with Km and Ki values some 5–10-fold higher. The high Km for pyruvate may be especially significant as this avoids loss of pyruvate from the cell which, were it to occur, would prevent removal of the reduced form of nicotinamide adenine dinucleotide (NADH) produced in glycolysis by reduction of pyruvate to lactate.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141526 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025161 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Price NT, Jackson VN, Halestrap AP (Jan 1998). "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past". The Biochemical Journal. 329 ( Pt 2) (2): 321–8. PMC 1219047. PMID 9425115.
  6. ^ "Entrez Gene: SLC16A3 solute carrier family 16, member 3 (monocarboxylic acid transporter 4)".

Further reading