|AHFS/Drugs.com||Micromedex Detailed Consumer Information|
|By mouth (tablets)|
|Elimination half-life||17–25 hours|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||495.63 g/mol g·mol−1|
|3D model (JSmol)|
|Melting point||128 °C (262 °F) (dihydrochloride salt)|
|(what is this?)|
The mechanism of action of mibefradil is characterized by the selective blockade of transient, low-voltage-activated (T-type) calcium channels over long-lasting, high-voltage-activated (L-type) calcium channels, which is probably responsible for many of its unique properties.
On June 8, 1998, Roche announced the voluntary withdrawal of the drug from the market, one year after approval by the FDA, due to the potential for drug interactions, some of them deadly, which may occur when it is taken together with some other medications.
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