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Metiapine Picture.jpg
Clinical data
Drug classTypical antipsychotic
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass323.458 g/mol g·mol−1
3D model (JSmol)

Metiapine is a typical antipsychotic medication of the dibenzothiazepine group.[1][2] There is scarce research on the safety and efficacy of metiapine in humans, though limited human trials exist.[2]

Medical uses

Metiapine has been investigated for the treatment of schizophrenia.[2]

Side effects

Like other typical antipsychotics, it has a high rate of extrapyramidal side effects.[3]


Metiapine has strong antidopaminergic effects and is classified as a typical (i.e., first-generation) antipsychotic.[3]


Metiapine is a dibenzothiazepine derivative.[2] Like clothiapine, metiapine has a sulfur atom replacing the nitrogen atom found in dibenzapine derivative antipsychotics like clozapine.[3]


Metiapine can be synthesized through the following mechanism:[4]
Metiapine Synthesis


Metiapine was first discovered in the 1970s by Marion Merrell Dow (now a part of Sanofi).[2]


A 2017 Cochrane Review provided guidance for a double-blind, randomized controlled trial of metiapine versus chlorpromazine for the treatment of schizophrenia, though the authors acknowledged that it is unlikely that any future trials will investigate the use of metiapine in humans.[2] The available evidence for the use of metiapine is very limited.[2]


  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 814–. ISBN 978-1-4757-2085-3.
  2. ^ a b c d e f g Zare, Morteza; Bazrafshan, Azam; Bazrafshan, Azam (2017). "Chlorpromazine versus metiapine for schizophrenia". doi:10.1002/14651858.CD011655.pub2. PMC 6464499. Cite journal requires |journal= (help)
  3. ^ a b c Baldessarini, Ross J. (1985). Chemotherapy in psychiatry : principles and practice (Rev. and enl. ed.). Cambridge, Massachusetts: Harvard University Press. ISBN 0674113837.
  4. ^ Ishar, M.P.S.; Faruk, Abdul (2006). Syntheses of organic medicinal compounds. Oxford: Alpha Science International. ISBN 184265280X.