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Clinical data
Trade namesTalis
ATC code
  • none
CAS Number
PubChem CID
Chemical and physical data
Molar mass393.705 g/mol g·mol−1
3D model (JSmol)

Metaclazepam[1] (marketed under the brand name Talis) is a drug which is a benzodiazepine derivative.[2][3] It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam.[4] It has an active metabolite N-desmethylmetaclazepam, which is the main metabolite of metaclazepam.[5] There is no significant difference in metabolism between younger and older individuals.[6]

Metaclazepam is slightly more effective as an anxiolytic than bromazepam,[7] or diazepam,[8] with a 15 mg dose of metaclazepam equivalent to 4 mg of bromazepam.[9] Metaclazepam can interact with alcohol producing additive sedative-hypnotic effects.[6][10] Fatigue is a common side effect from metaclazepam at high doses.[11] Small amounts of metaclazepam as well as its metabolites enter into human breast milk.[12]

See also


  1. ^ US Patent 4098786
  2. ^ Borchers, F.; Achtert, G.; Hausleiter, HJ.; Zeugner, H. (1984). "Metabolism and pharmacokinetics of metaclazepam (Talis), Part III: Determination of the chemical structure of metabolites in dogs, rabbits and men". Eur J Drug Metab Pharmacokinet. 9 (4): 325–46. doi:10.1007/bf03189684. PMID 6532806.
  3. ^ Althaus, W.; Block, J.; Förster, A.; Kühnhold, M.; Meister, D.; Wischniewski, M. (Sep 1986). "Analytical profile of metaclazepam". Arzneimittelforschung. 36 (9): 1302–6. PMID 3790179.
  4. ^ Buschmann, G.; Kühl, UG.; Rohte, O. (1985). "General pharmacology of the anxiolytic compound metaclazepam in comparison to other benzodiazepines". Arzneimittelforschung. 35 (11): 1643–55. PMID 2868732.
  5. ^ Gielsdorf, W.; Molz, KH.; Hausleiter, HJ.; Achtert, G.; Philipp, P. "Pharmacokinetic profile of metaclazepam (Talis), a new 1.4-benzodiazepine. Influence of different dosage regimens on the pharmacokinetic profile of metaclazepam and its main metabolite under steady-state conditions". Eur J Drug Metab Pharmacokinet. 11 (3): 205–10. doi:10.1007/bf03189848. PMID 3816876.
  6. ^ a b Molz, KH.; Gielsdorf, W.; Rasper, J.; Jaeger, H.; Hausleiter, HJ.; Achtert, G.; Philipp, P. (1985). "Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers". Eur J Clin Pharmacol. 29 (2): 247–9. doi:10.1007/bf00547431. PMID 4076323.
  7. ^ Bilone, F.; Roncari, R. (1988). "A double-blind comparison of the anxiolytic activity of two benzodiazepines, metaclazepam and bromazepam, in anxiety neurosis". Curr Med Res Opin. 11 (1): 45–7. doi:10.1185/03007998809111130. PMID 2898321.
  8. ^ Laakmann, G.; Blaschke, D.; Hippius, H.; Schewe, S. (May 1989). "Double-blind study of metaclazepam versus diazepam treatment of outpatients with anxiety syndrome". Pharmacopsychiatry. 22 (3): 120–5. doi:10.1055/s-2007-1014593. PMID 2568645.
  9. ^ Marano, P.; Patti, F.; Nicoletti, F. (1988). "Controlled study on the anxiolytic activity of a newly developed benzodiazepine, metaclazepam". Curr Med Res Opin. 11 (1): 41–4. doi:10.1185/03007998809111129. PMID 2898320.
  10. ^ Schmidt, V. (1983). "[Experimental studies on the interaction of alcohol and metaclazepam]". Beitr Gerichtl Med. 41: 413–7. PMID 6639614.
  11. ^ Laakmann, G.; Blaschke, D.; Hippius, H.; Schewe, S. (May 1988). "Double-blind randomized trial of the benzodiazepine derivative metaclazepam as compared with placebo treatment of outpatients with anxiety syndromes". Pharmacopsychiatry. 21 (3): 136–43. doi:10.1055/s-2007-1014665. PMID 2900514.
  12. ^ Schotter, A.; Müller, R.; Günther, C.; Hausleiter, HJ.; Achtert, G. (Nov 1989). "Transfer of metaclazepam and its metabolites into breast milk". Arzneimittelforschung. 39 (11): 1468–70. PMID 2575907.