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Megestrol

Megestrol
Megestrol.svg
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard100.020.571 Edit this at Wikidata
Chemical and physical data
FormulaC22H30O3
Molar mass342.472 g/mol g·mol−1
3D model (JSmol)
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Megestrol (INN, BAN) is a progestin of the 17α-hydroxyprogesterone group which was never marketed and is not currently used clinically.[1][2] Its acylated derivative megestrol acetate is also a progestogen, which, in contrast to megestrol itself, has been extensively used as a pharmaceutical drug.[1][2]

Synthesis

Megestrol synthesis:[3] U.S. Patent 2,891,079

See also

References

  1. ^ a b F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1267. ISBN 978-0-412-46630-4. Retrieved 12 May 2012.
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 641. ISBN 978-3-88763-075-1. Retrieved 28 May 2012.
  3. ^ Ringold, H. J.; Ruelas, J. P.; Batres, E.; Djerassi, C. (1959). "Steroids. CXVIII.16-Methyl Derivatives of 17α-Hydroxyprogesterone and of Reichstein's Substance "S"". Journal of the American Chemical Society. 81 (14): 3712. doi:10.1021/ja01523a055.