Medifoxamine, previously sold under the brand names Clédial and Gerdaxyl, is an atypical antidepressant with additional  anxiolytic properties acting via  dopaminergic and serotonergic mechanisms which was formerly marketed in France and Spain, as well as Morocco.     The drug was first introduced in France sometime around 1990.  It was  withdrawn from the market in 1999 (Morocco) and 2000 (France) following incidences of hepatotoxicity.  
Medifoxamine has been found to act preferentially as a relatively weak
dopamine reuptake inhibitor,    but also as an even weaker  serotonin reuptake inhibitor ( IC = 1,500 nM) 50 and as a weak  antagonist of the 5-HT and 2A 5-HT (IC 2C receptors 50 = 950 and 980, respectively; notably greater affinity relative to amitriptyline and imipramine).   It is known to produce two  active metabolites during first-pass metabolism in the liver, CRE-10086 (N-methyl-2,2-diphenoxyethylamine) and CRE-10357 (N,N-dimethyl-2-hydroxyphenoxy-2-phenoxyethylamine). The IC  50 values of CRE-10086 for serotonin transporter, 5-HT 2A, and 5-HT 2C binding are 450 nM, 330 nM, and 700 nM, respectively, while those of CRE-10357 are 660 nM, 1,600 nM, and 6,300 M. Medifoxamine and its metabolites lack affinity for other  serotonin receptors including 5-HT, 1A 5-HT, 1B 5-HT, and 1D 5-HT (>10,000 nM). 3 As medifoxamine is metabolized extensively in the liver during first-pass metabolism, and as these metabolites have as much as 3-fold greater activity relative to medifoxamine, it is likely that they contribute significantly to the  pharmacology of the parent drug.
Effectiveness and tolerability
tricyclic antidepressants, medifoxamine lacks anticholinergic and alpha blocker properties (very low affinity for the muscarinic acetylcholine receptors and 10-fold lower affinity for the α relative to 5-HT 1-adrenergic receptor 2 binding sites),   and is also apparently inactive as a  norepinephrine reuptake inhibitor (although the same source stating this also states that it is inactive as a serotonin reuptake inhibitor, which was subsequently found not to be the case). Studies in mice revealed that the drug does not possess any  sedative or locomotor stimulant effects. In accordance with all of the preceding, medifoxamine was found to be  well tolerated at dosages of 100–300 mg per day in clinical trials.  Double-blind controlled clinical studies have found it to have similar effectiveness to imipramine, clomipramine, and maprotiline in the treatment of depression.   
Society and culture
Medifoxamine is the generic name of the drug and its while INN médifoxamine is its . DCF  
Medifoxamine was marketed under the brand names Clédial and Gerdaxyl.
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