Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions; specifically stomach pain and cramps, persistent diarrhea, and flatulence.
Data from controlled clinical trials have not found a difference from placebo in the alleviating stomach pain in people with IBS.
It has not been tested in pregnant women nor in pregnant animals so pregnant women should not take it; it is expressed at low levels in breast milk, while no adverse effects have been reported in infants, breastfeeding women should not take this drug.
Adverse effects include hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, edema and widespread rashes.
Additionally, the following adverse effects have been reported: heartburn, indigestion, tiredness, diarrhea, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate.
^Hatami, Mehdi; Farhadi, Khalil; Tukmechi, Amir (August 2012). "Fiber‐Based Liquid‐Phase Micro‐Extraction of Mebeverine Enantiomers Followed by Chiral High‐Performance Liquid Chromatography Analysis and Its Application to Pharmacokinetics Study in Rat Plasma". Chirality. 24 (8): 634–639. doi:10.1002/chir.22057. PMID22700279.