Byzantine Izala fell to the Seljuks in the 11th century.
During the Artuqid period, many of Mardin's historic buildings were constructed, including several mosques, palaces, madrassas and khans. Mardin served as the capital of one of the two Artuqid branches during the 11th and 12th centuries. The lands of the Artukid dynasty fell to the Mongol invasion sometime between 1235 and 1243, but the Artuqids continued to govern as vassals of the Mongol Empire.
During the battle of Ain Jalut in 1260, the Artuqid governor revolted against Mongol rule. Hulagu's general and Chupan's ancestor, Koke-Ilge of the Jalayir, stormed the city and Hulegu appointed the rebel's son, al-Nasir, governor of Mardin.
Although, Hulagu suspected the latter's loyalty for a while, thereafter the Artuqids remained loyal unlike nomadic Bedouin and Kurd tribes in the south western frontier. The Mongol Ilkhanids considered them important allies. For this loyalty they showed, Artuqids were given more lands in 1298 and 1304.
Mardin later passed to the Aq Qoyunlu, a federation of Turkic tribes that controlled territory all the way to the Caspian Sea.
In 1451 the Kara Koyunlu besieged the castle of Mardin, damaging the city after their failed attempt to take the stronghold. About half a century later, in 1507, Ismail I of the Safavids succeeded to capture the city and the castle. A few years later in 1515, the city yielded to the Ottomans, who were bitter rivals of the Safavid dynasty, though the castle still remained under the control of Ismail I. One year later, the Ottomans under the leadership of Selim I besieged the city anew and eventually annexed it in 1517. During this time, Mardin was administered by a governor directly appointed under the Ottoman Sultan's authority.
The city experienced a relatively tranquil period under Ottoman rule, without any significant conflicts or plights. This period of peace was finally halted when the Ottoman Empire came into conflict with the Khedivate of Egypt. During this time the city came under the rule of insurgents associated with the Milli clan. Between 1847 and 1865 the city's population suffered from a notable cholera epidemic, with the exact number of fatalities not known. During World War I Mardin was one of the sites affected by the Armenian Genocide. On the eve of World War I, Mardin was home to over 12,000 Assyrians and over 7,500 Armenians. During the armed conflicts and plights caused by the war, many were sent to the camps of Ras al-'Ayn, though some managed to escape to the Sinjar Mountain with help from local Chechens. Kurds and Arabs of Mardin typically refer to these events as "fırman" (government order), while Syriacs call it "seyfo" (sword). After the Armistice of Mudros Mardin was one of the Turkish cities that was not occupied by the troops of the Allied Powers. In 1923, with the founding of the Republic of Turkey, Mardin was made the administrative capital of a province named after it. Many Assyrian survivors of the violence later on left Mardin for nearby Qamishli in the 1940s after their conscription in the Turkish military became compulsory.
Mardin has often been considered an open-air museum due to its historical architecture. Most buildings use the beige colored limestone rock which has been mined for centuries in quarries around the area.
Mor Mihail Church -A Syriac Orthodox Church located on the southern edge of Mardin.
Mor Simuni Church - A Syriac Orthodox Church with a large courtyard.
Mor Petrus and Pavlus (SS. Peter and Paul) Church - A 160 year old Assyrian Protestant Church, recently renovated.
Mor Cercis Church
Deyrü'z-Zafaran Monastery or The Monastery of St. Ananias is 5 kilometres south east of the city. The Syriac Orthodox Saffron Monastery was founded in 493 AD and is one of the oldest monasteries in the world and the largest in Southern Turkey, alongside Mor Gabriel Monastery. From 1160 until 1932, it was the seat of the Syriac Orthodox Patriarch, until the Patriarchate relocated to the Syrian capital Damascus. The site of the monastery itself is said to have been used as a temple by sun worshipers as long ago as 2000 BC.
The Great Mosque of Mardin
Great Mosque (Ulu Camii) - constructed in the 12th century by the ruler of the Artukid Turks, Qutb ad-din Ilghazi. It has a ribbed dome and a minaret that soars above the city. There were originally two minarets, but one collapsed many centuries ago.
Melik Mahmut Mosque - built in the 14th century and contains the tomb of its patron Melik Mahmut. It is known for its large gate which features elaborate stonework.
Abdüllatif Mosque (Latfiye Mosque) - built in 1371 by the Artukid ruler Abdüllatif. Its minaret was destroyed by Tamerlane's army and rebuilt many centuries later in 1845 by the Ottoman Governor Gürcü Mehmet Pasha.
Şehidiye Medresse and Mosque - built in 1214 by Artuk Aslan. It has an elaborate ribbed minaret and an adjoining madrassa.
Necmettin Gazi Mosque
Kasım Tuğmaner Mosque
Reyhaniye Mosque - the second largest mosque in Mardin after Ulu Camii. Built in the 15th century, it has a large courtyard and open hallway featuring a fountain.
Hamidiye Mosque (Zebuni Mosque) - built before the 15th century, it is named after its patron Şeyh Hamit Effendi.
Secaattin and Mehmet Mosque
Hamza-i Kebir Mosque
Şeyh Abdülaziz Mosque
Melik Eminettin el-Emin Mosque
Sıtra Zaviye Mosque
Şeyh Salih Mosque
Mahmut Türki Mosque
Şeyh Çabuk Mosque - built in the 14th century and contains the tomb of its patron Şeyh Çabuk
Nizamettin Begaz Mosque
Zinciriye Medrese (Sultan Isa Medrese) - constructed in 1385 by Najm ad-din Isa. The madrasa is part of a complex that includes a mosque and the tomb of Najm ad-din Isa.
Sitti Radviyye Medrese (Hatuniye Medrese) - built in the 12th century in the honor of Sitti Radviyye, the wife of Najm ad-din Alpi. There is a footprint that is claimed to be that to be that of the Prophet Muhammad.
Historically, Mardin produced sesame. Tourism is an important industry in Mardin.
During the late Permian ~250 mya the Afro-Arabian plate started opening up. The East African continental rift initiation is believed to have started around 27-31 million years ago with the beginning of the basaltic volcanism of the Afar Plume. This rift system would cause a contractional tectonic process to occur in which the Arabian Plate was pushed in a north-easterly direction towards the Eurasian plate. The divergence in the East African Rift would eventually cause the closure of the Tethys Ocean as the Arabian Plate made its first inception of collision with Eurasia between 25-23 million years ago, and complete closure around 10 mya and creation of the Mardin High.
Mardin has a hot-summer Mediterranean climate with hot, dry summers and cold, wet, and occasionally snowy winters. Temperatures in summer usually increase to 40 °C (104 °F) due to Mardin being situated right next to the border of Syria. Snowfall is quite common between the months of December and March, snowing for a week or two. Mardin has over 3000 hours of sun per year. The highest recorded temperature is 42.5 °C (108.5 °F). Average rainfall is about 641.4 mm (25 inches) per year.
Mardin-Kızıltepe, with +48.8 °C (119.84 °F) on August 14, 1993, holds the record for the highest temperature ever recorded in Turkey.
^Besides, in the Behistun inscription, Izalla, the region of Syria renowned for its wine, is assigned to Athura. George Roux - Ancient Iraq
^Johann Elieser Theodor Wiltsch, trans. John Leitch, Handbook of the Geography and Statistics of the Church, Volume 1, Bosworth & Harrison, 1859, [books.google.ch/books?id=DbwpAAAAYAAJ&pg=PA232 p. 232.]