The town obtained its town charter in 1421. Before 1939 about 7000 people lived in Maków, including 3000 Jews and 4000 Poles. The Jewish community was murdered during the Nazi German occupation, in the Holocaust.
While a secret protocol had been struck prior to World War II between Nazi Germany and the Soviet Union that laid plans to split up Poland between them, Germany later abrogated this agreement and struck deeply into Russian territory. In the course of Maków Mazowiecki being seized from the Germans by a counter-attacking Red Army in January 1945, heavy fighting and artillery barrages destroyed 90% of the town's buildings.
Leib Langfus - Rabbi from Makow, later murdered in Auschwitz-Birkenau. His diary of his deportation and time in Auschwitz-Birkenau are considered one of the most valuable Holocaust era eyewitness testimonies.