Lycorine is found in different species of Amaryllidaceae which include flowers and bulbs of daffodil, snowdrop (Galanthus) or spider lily (Lycoris). Lycorine is the most frequent alkaloid of Amaryllidaceae.
The earliest diversification of Amaryllidaceae was most likely in North Africa and the Iberian peninsula and that lycorine is one of the oldest in the Amaryllidaceae alkaloid biosynthetic pathway.
Mechanism of action
There is currently very little known about the mechanism of lycorine. There are tentative ideas about how lycorine metabolizes due to a study done on beagle dogs.
Lycorine inhibits protein synthesis, and may inhibit ascorbic acidbiosynthesis, although studies on the latter are controversial and inconclusive. Presently, it serves some interest in the study of certain yeasts, the principal organism on which lycorine is tested.
It is known that lycorine weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis. The IC50 of lycorine was found to vary between the different species it can be found in but a common deduction from the experiments on lycorine was that it had some affect on inhibiting AChE.
Lycorine exhibits cytostatic effects by targeting the actincytoskeleton rather than by inducing apoptosis in cancer cells, though lycorine was found to apoptosis at different stages in a cells cycle.
This is a possible lycorine synthesis from O-Methylnorbelladine found in the species Amaryllidaceae
One possible synthesis of lycorine could come from O-Methylnorbelladine, which can be seen in the image to the right.
The poisoning of lycorine typically occurs with the ingestion of daffodil bulbs.
Daffodil bulbs are sometimes confused with onions, leading to accidental poisoning.
In a study of dosage used on beagle dogs, the first sign of nausea was observed at as little of a does of 0.5 mg/kg and occurred within a 2.5 hour span. The effective dose to induce emesis in the dogs was seen to be 2.0 mg/kg and lasted no longer than 2.5 hours after administration.
Lycorine has been seen to have promising biological and pharmacological activities such as antibacterial, antiviral, or anti-inflammatory effects and may have anticancer properties. It has displayed various inhibitory properties towards multiple cancer cell lines that include, lymphoma, carcinoma, multiple myeloma, melanoma, leukemia, human A549 non-small-cell lung cancer, human OE21 esophageal cancer and more.
Lycorine has many derivatives used for anti-cancer research such as lycorine hydrochloride (LH) which is a novel anti-ovarian cancer agent, and data has shown that LH effectively inhibited mitotic proliferation of Hey1B cells with very low toxicity. This drug could be used for effective anti-ovarian cancer therapy in the future.